4.4 ANS Medication Classes and Nursing Considerations

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Classes of medication, categorized according to neuroreceptor, are further discussed in more detail below. Table 4.2[1] contrasts agonist and antagonist medications for each ANS neuroreceptor.

Table 4.2 Comparison of Prototype Medications that Stimulate Versus Inhibit PNS and SNS Receptors

Receptor
Stimulation (Agonist)
Inhibition (Antagonist)
Nicotine Nicotine is a muscle relaxant with CNS effects. Nicotine patch is used for nicotine addiction by slowly reducing dose and avoiding withdrawal effects Not clinically applicable
Muscarinic Pilocarpine causes muscle contraction; assists with glaucoma by contracting ciliary muscle and draining fluid Atropine in small doses inhibits secretions; in moderate doses increases heart rate; in large doses decreases gastrointestinal motility
Alpha-1 Pseudoephedrine and Phenylephrine cause vasoconstriction, decreased swelling of mucus membranes, and decreased secretions Tamsulosin relaxes smooth muscle in bladder/prostate to improve urine flow and also decreases blood pressure due to vasodilation
Alpha-2 Clonidine decreases CNS outflow to treat ADHD and also reduces blood pressure and heart rate Limited clinical use
Beta-1 Dobutamine increases heart rate, force of heart contraction, and speed of conduction between SA to AV nodes Selective B blocker: Metoprolol works on Beta-1 receptors to decrease blood pressure and heart rate
Beta-2 Albuterol used for bronchodilation Nonselective B blocker: Propranolol works on Beta-2 and Beta-1 receptors; decreases blood pressure but can also cause bronchoconstriction
Catecholamines stimulate multiple adrenergic receptors Epinephrine and Norepinephrine: stimulate alpha- and beta-receptors on target organs, causing increased heart rate and vasoconstriction for improved blood flow to essential organs

Dopamine has dose-dependent effects that target arteries in the kidneys, heart, and brain

Not clinically applicable

 

Supplementary Videos:  See the supplementary videos below related to sympathetic and parasympathetic nervous system medications.

Sympathetic Nervous System Drugs

[2]

 

Parasympathetic Nervous System Drugs

[3]

 


  1. This work is a derivative of Daily Med by U.S. National Library of Medicine in the public domain
  2. Forciea, B. (2018, January 12). Sympathetic nervous system drugs. [Video]. YouTube. All rights reserved.  Video used with permission.  https://youtu.be/-e_s-jTPtm4
  3. Forciea, B. (2018, February 2). Parasympathetic nervous system drugs. [Video]. YouTube. All rights reserved. Video used with permission. https://youtu.be/ZSRk_NkbBPg

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